QLG funded projects

Members of the QLG are also engaged in a number of clinical and methodological projects, all aiming, in one way or another, to provide the means to ensure that patients’ voices are heard loud and clear in clinical and translational research on a daily basis.

This page will give you an overview of the many different activities.

• Minimal Important Difference (MID)

• Evaluating content validity of the EORTC QLQ-C30

• Development of response criteria for longitudinal health-related quality of life data in oncology clinical trials (Q-RECIST)

• Development of thresholds for the EORTC QLQ-C30 and the EORTC CAT measures to enable their use for symptom screening in daily clinical practice

• Development of EORTC/CLTF questionnaires to assess HRQOL in primary cutaneous T-cell and B-cell lymphomas: Phase I-II.

• Investigating and improving the German response scales of the EORTC core questionnaire for assessing the quality of life in cancer patients (EORTC QLQ-C30) – a three-step approach

• Development and evaluation of an e-learning programme on EORTC Quality of life measures in clinical practice) QOL_E-Learning

• Update of the EORTC QLQ reference values manual (RefVal)

• Prospective Minimal Important Difference (pMID) Project: Interpreting changes in EORTC QLQ-C30 scores by anchoring to patients’ rating of change – Phase I

• Improving compliance and standard of data collection and use in trials: setting standards for the next generation

• Development of an interpretation guideline for the EORTC PRO measures

• Measurement strategies in progressive disease

• STRONG AYA

• REQUALIFY

Reworking the QLG guidelines for assessing Quality of Life in EORTC clinical trials – updating and rewriting by incorporating cutting-edge advice on PROs and input from relevant QLG projects

• A critical review of the use of electronic patient-reported outcomes in cancer clinical trials – developing an EORTC perspective

• Facilitating the representation of EORTC QoL Modules and items in common data models

• Development of recommendations for use of EORTC QLG-C30 summary score in cancer clinical trials and clinical practice

• Development and validation of the EORTC computerized adaptive testing (CAT) instrument

• Comparative evaluation of the computer-adaptive EORTC quality of life measures

• Collection of Normative Data for the EORTC CAT

• Development of thresholds for the EORTC QLQ-C30 and the EORTC CAT measures to enable their use for symptom screening in daily clinical practice

• Evaluating the use of the EORTC PRO measures for improving inter-rater reliability of CTCAE ratings

• Determination of European Utility Weights for a Cancer-Specific Preference-Based Quality of Life Measure Derived From the EORTC QLQ-C30

• Comparison of the EORTC QLU-C10D with generic utility instruments and development of a comprehensive manual for its use

• Establishing thresholds for clinical importance for disease-specific EORTC questionnaire modules

• Expanding partnerships with patients and carers in the EORTC to optimize clinical trials and quality of life measurement

• Item Library Guidelines

• Follow-up in Early and Locally Advanced Breast Cancer Patients: An EORTC QLG-BCG-ROG Protocol

• Routine Follow-up of Gynecological Cancer Patients: A joint EORTC QLG-GCG protocol

• Assessment of the Quality of Life of childhood acute lymphoblastic leukemia patients enrolled in EORTC Children Leukemia Group trials between 1971 and 1998

• Late Toxicity and Long-term Quality of Life in Head and Neck Cancer Survivors

• Long-term Quality of Life in Acute Myeloid Leukemia Survivors Treated in Randomized Controlled Trials and in Real-Life Settings

• Understanding the long-term implications of treatment of rare brain tumours on health-related quality of life: A European cross-sectional study

• Long-term survivorship challenges of advanced/metastatic GIST patients responding to Imatinib treatment: An observational study

• Type and DIREction of Clinical and patient-reported outcomes in cancer Trials RepositORY Project (DIRECTORY)

• Predictors of quality of life ratings from patients with primary brain tumors: the role of self-awareness and cognitive functioning

• Combining clinical trial datasets in glioma patients: the added value of health-related QOL assessment (CODAGLIO)

• Cancer Clinical Trials Pooling of Quality Life Data (CATAPULT) initiative