The EORTC QLQ-C30 is a widely used and well validated instrument that is designed to assess health-related quality of life in patients with cancer. Since the original development of the questionnaire in 1987 the treatment landscape has changed and also different methodology for developing instruments has emerged as standard. In order to collect additional information to support the content validity of the EORTC QLQ-C30, new interviews with patients are being conducted to confirm the content validity of the QLQ-C30.
The overall objective of the study is to collect evidence to address the extent to which the QLQ-C30 reflects the issues relevant to cancer patients given the original intended conceptual framework.
A total of 120 qualitative semi-structured interviews lasting approximately 60-90 minutes are being conducted. Patients will be recruited from sites across Europe and the United States (US). The interview consists of three sections: open ended concept elicitation, more structured discussion of the QLQ-C30 domains, and debriefing of the QLQ-C30. Qualitative thematic analysis is being conducted and results disseminated via publication and conferences.
An initial review of the EORTC disease-specific modules has been completed. This was presented at the ISOQOL conference in 2016.
The methodology for confirming content validity of existing legacy instruments was presented at ISOQOL in 2017.
The protocol and interview guide were developed and sites across Europe and in the US have been obtaining ethical approvals to participate in the study.
A total of 82 interviews have been conducted to date in USA (n=28), UK (n=18) Germany (n=10), Netherlands (n=13), Poland (n=10) and Italy (n=3).
Recruitment is ongoing. Analysis of the interviews carried out to date is in progress.
Recruitment will be ongoing until approximately April 2019. The analysis is expected by Autumn 2019 followed by dissemination.
The EORTC QLQ-C30 is a questionnaire that is designed to measure the quality of life of people with cancer. This questionnaire was originally written in 1987. Since then new cancer treatments have been developed and this work will check it still asks questions that are important and relevant for cancer patients today. A total of 120 people with different types of cancer from Europe and the United States are being interviewed.