Threshold for the EORTC QLQ-C30 and CAT

Principal investigator(s)
Johannes Giesinger
Department of Psychiatry, Psychotherapy and Psychosomatics Medical University of Innsbruck
Innsbruck, Austria

Project summary

To improve interpretation of patient-reported outcome (PRO) data collected with the EORTC QOL measures the project develops thresholds for clinical importance. These thresholds will facilitate interpretation of QOL scores collected in daily clinical practice and of trial results.


Recruitment for the project has been finished (N=650 participants in total). A manuscript on thresholds for the QLQ-C30 has been drafted, and the writing of a further manuscript on thresholds for the EORTC CAT measures is ongoing.

The last publication from this project is being drafted.

Future plans

The project will be closed after submission of the final manuscript.

For patients

The EORTC quality of life questionnaires are used to assess the perspective of cancer patients on their disease and its treatment. Such questionnaires allow to calculate scores that reflect the degree of a symptom or problem. Relying on interviews with cancer patients and health professionals, this project develops thresholds that help to determine what degree of a symptom or problem should be considered clinically important.


  • Giesinger JM, Aaronson NK, Arraras JI, Efficace F, Groenvold M, Kieffer JM, Loth FL, Petersen MA, Ramage J, Tomaszewski KA, Young T, Holzner B; EORTC Quality of Life Group. A cross-cultural convergent parallel mixed methods study of what makes a cancer-related symptom or functional health problem clinically important. Psychooncology. 2018 Feb;27(2):548-555.