Comparison of the EORTC QLU-C10D

Principal investigator(s)
Eva Maria Gamper
Medical University of Innsbruck Department for Psychiatry, Psychotherapy, and Psychosomatic Medicine
Innsbruck, Austria
Project coordinator(s)
Micha Pilz
Medical University of Innsbruck
Innsbruck, Austria

Project summary

The QLU-C10D is a newly developed, cancer-specific multi-attribute utility instrument (MAUI) which has been included in the EORTC assessment system and can be used for health economic evaluations in cost-utility analyses (CUA). The most commonly used utility instruments are generic, i.e. cover overal aspects of functioning only. The QLU-C10D is based on the QLQ-C30 and includes 10 of its 15 domains. Therefore, it is considered to capture symtpoms and functioning aspects specific to cancer patients and to be more sensitive in this patient group.

The present study aims at assessing the relative validity of the QLU-C10D in cancer patients compared to the most widely used generic utilty instruments, such as the EQ-5D and the SF-6D. Furthermore, a manual for the use of the QLU-C10D in CUAs will be developed.


Prospective data collection (Austria and France) has been completed and analyses are ongoing.

A systematic literature and trial data base search has identified >50 oncology trials potentially eligible for our retrospective analyses. Five data sets from academic studies and 6 data sets from industry funded/conducted studies could be used for analyses. Results are being published and indicate good clinical validity of the QLU-C10D. Analyses of 2 data sets are outstanding.

Relative validity in comparison with the EQ-5D-3L in retrospective trial analyses likewise was good, comparison with the EQ-5D-5L and the SF-6D are currently outstanding.

An international and multi professional  working group within the project has drafted a user manual for the QLU-C10D which is ready for external review.

QLU-C10D norm data have been developed for 5 countries and are currently being published.


Future plans

Analyses of prospective data by the end of 2022, publication of results by June 2023.

Publication of all retrospective trial data analyses by the June 2023.

Finalization of QLU-C10D manual by the end of  2022.



For patients

The QLU-C10D is a kind of questionnaire, developed to capture cancer patients’ quality of life and to relate it to survival time and costs of treatment in health economic studies. The study investigates whether the QLU-C10D is able to capture cancer patients’ quality of life issues more precisely than generic questionnaires which were not designed specifically for cancer patients.


Accepted conference abstract at ISOQOL:

  • Oral Brief Presentation: Cancer-specific and generic health utilities – The psychometric performance of the EORTC QLU-C10D in comparison to the EQ-5D in three cancer clinical trials
  • Poster: The EORTC QLU-C10D – development and investigation of general population utility norms for Canada, France, Germany, Italy, Poland and the UK