Comparison of the EORTC QLU-C10D

Principal investigator(s)
Eva Maria Gamper
Medical University of Innsbruck Department for Psychiatry, Psychotherapy, and Psychosomatic Medicine
Innsbruck, Austria
Project coordinator(s)
Micha Pilz
Medical University of Innsbruck
Innsbruck, Austria

Project summary

The QLU-C10D is a newly developed, cancer-specific multi-attribute utility instrument (MAUI) which has been included in the EORTC assessment system and can be used for health economic evaluations in cost-utility analyses (CUA). The most commonly used utility instruments are generic, i.e. cover overal aspects of functioning only. The QLU-C10D is based on the QLQ-C30 and includes 10 of its 15 domains. Therefore, it is considered to capture symtpoms and functioning aspects specific to cancer patients and to be more sensitive in this patient group.

The present study aims at assessing the relative validity of the QLU-C10D in cancer patients compared to the most widely used generic utilty instruments, such as the EQ-5D and the SF-6D. Furthermore, a manual for the use of the QLU-C10D in CUAs will be developed.


Prospective data collection has been set up in Austria and France.

A systematic literature and trial data base search has yielded in a list of >50 oncology trials that may be eligible for our retrospective analyses and data owners have been contacted.

Prospective data collection is ongoing.

Researchers have shared their trial data sets for retrospective analyses which are currently being performed.

The writing of the manual for the use of the QLU-C10D has been started by an international and multiprofessional  working group within the project.

First results on the clinical validity of the QLU-C10D will be available soon

Future plans

First analyses of prospectively collected data in Austria: spring 2020.

First publication on retrospective trial data analyses: autumn 2019

Draft of QLU-C10D manual for internal review: summer 2019

For patients

The QLU-C10D is a kind of questionnaire, developed to capture cancer patients’ quality of life and to relate it to survival time and costs of treatment in health economic studies. The study investigates whether the QLU-C10D is able to capture cancer patients’ quality of life issues more precisely than generic questionnaires which were not designed specifically for cancer patients.


Accepted conference abstract at ISOQOL:

  • Oral Brief Presentation: Cancer-specific and generic health utilities – The psychometric performance of the EORTC QLU-C10D in comparison to the EQ-5D in three cancer clinical trials
  • Poster: The EORTC QLU-C10D – development and investigation of general population utility norms for Canada, France, Germany, Italy, Poland and the UK