Principal investigator(s)
Georg Kemmler
Medical University of Innsbruck
Innsbruck, Austria
Project coordinator(s)
Jens Lehman
Medical University of Innsbruck
Innsbruck, Austria

Project summary

To make the QLQ-C30 applicable for health economic evaluations, a cancer-specific utility instrument based on ten dimensions of the QLQ-C30, the QLU-C10D, was developed. This present project, a continuation of the first QLU-C10D valuation project, aims to make EORTC QLQ-C30 data applicable for health economic evaluations in five further European countries and one Asian country. We are collecting data on how people from different countries value aspects of quality of life and which domains are particularly important to them. This is done by calculating country-specific utility weights using the EORTC QLU-C10D. A secondary objective of the project is to investigate the methodological robustness of utility weights. As of July 2025, the project is successfully closed.

Achievements

The valuation studies in all countries (Sweden, Norway, Hungary, South Korea, Belgium, and Portugal) have been completed and manuscripts have been published or submitted.

A summary of the completed valuation studies across all QLU/MAUCa projects is shown in Figure 1.

Figure note. Countries for which EORTC QLU-C10D value sets have been published in peer-reviewed journals (as of March 2025): Australia, Austria, Canada, China, Denmark, France, Germany, Hong Kong, Italy, Japan, Norway, Poland, Spain, Sweden, The Netherlands, United Kingdom, United States.

Further, the country-specific value sets for the following countries have been developed: Belgium, Hungary, Portugal, South Korea.

Future plans

This study is now completed.

For patients

We are collecting data on how people from different countries value aspects of quality of life and which of these are particularly important to them. It is important to do this for individual countries separately, as people’s preferences differ between countries.

This project is a continuation of our first QLU-C10D valuation project. The QLU-C10D is required for health-economic evaluations using the QLQ-C30. The first EORTC project covered five European countries. The new project extends the old one by establishing the required “utility weights” for a further six countries, five European and one Asian country: Sweden, Norway, Belgium, Portugal, Hungary, and South Korea. This project has now been successfully completed.

Publications

  • Rohde G, Lehmann J, Pilz MJ, Rojas-Concha L, Holzner B, King MT, Norman R, Kemmler G; EORTC Quality of Life Group. Norwegian and Swedish value sets for the EORTC QLU-C10D utility instrument. Qual Life Res. 2025 Feb;34(2):429-443. doi: 10.1007/s11136-024-03824-8. Epub 2024 Nov 5. PMID: 39499479; PMCID: PMC11865156..
  • Cao Y, Xu J, Norman R, King MT, Kemmler G, Huang W, Luo N. Chinese utility weights for the EORTC cancer-specific utility instrument QLU-C10D. Qual Life Res. 2024 Sep 13. doi: 10.1007/s11136-024-03776-z. Epub ahead of print. PMID: 39269580.
  • Xu RH, Wong EL, Luo N, Norman R, Lehmann J, Holzner B, King MT, Kemmler G; EORTC QLG. The EORTC QLU-C10D: the Hong Kong valuation study. Eur J Health Econ. 2024 Jul;25(5):889-901. doi: 10.1007/s10198-023-01632-4. Epub 2023 Sep 28. PMID: 37768519.
  • Jansen F, Verdonck-de Leeuw IM, Gamper E, Norman R, Holzner B, King M, Kemmler G; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group. Dutch utility weights for the EORTC cancer-specific utility instrument: the Dutch EORTC QLU-C10D. Qual Life Res. 2021 Jul;30(7):2009-2019. doi: 10.1007/s11136-021-02767-8. Epub 2021 Jan 29. PMID: 33512653; PMCID: PMC8233279.
  • Finch AP et al. Estimation of an EORTC QLU-C10D value set for Spain using a discrete choice experiment. Pharmacoeconomics. 2021 Sep;39(9):1085-109
  • Lehmann J et al. Functional health and symptoms in Spain before and during the COVID-19 pandemic. BMC Public Health. 2021 May 1;21(1):837.
  • Gamper EM, King MT, Norman R, Efficace F, Cottone F, Holzner B, Kemmler G. EORTC QLU-C10D value sets for Austria, Italy, and Poland. Qual Life Res. 2020 May 26  Available from: https://doi.org/10.1007/s11136-020-02536-z
  • Nerich V, Gamper EM, Norman R, King M, Holzner B, Viney R, Kemmler G. French Value-Set of the QLU-C10D, a cancer-specific utility measure derived from the QLQ-C30. Appl Health Econ Health Policy. 2020 Jun 15. doi: 10.1007/s40258-020-00598-1. PMID: 32537694
  • Kemmler G, Gamper E, Nerich V, Norman R, Viney R, Holzner B, King M. German value sets for the EORTC QLU-C10D, a cancer-specific utility instrument based on the EORTC QLQ-C30. Qual Life Res. 2019 Dec;28(12):3197-3211.
  • Kemmler G, Gamper E et al. (2018): Preferences for life domains differ across countries – findings from the QLU-C10D valuation project. Proceedings of the 25th Annual Conference of the ISOQOL. Abstract 3098.
  • King MT, Viney R, Pickard AS, Rowen D, Aaronson NK, Brazier JE, Cella DF, Costa DSJ, Fayers PM, Kemmler G, McTaggart-Cowen H, Mercieca-Bebber R, Peacock S, Street D, Young TA, Norman R (2018). Australian utility weights for the EORTC QLU-C10D, a multi-attribute utility instrument derived from the cancer-specific quality of life questionnaire, EORTC QLQ-C30. Pharmaco-Economics, 36(2):225-238.
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