Acute Myeloid Leukemia Survivors

Principal investigator(s)
Fabio Efficace
GIMEMA
Rome, Italy
, Frédéric Baron
University of Liège
Liège, Belgium
Project coordinator(s)
Laura Cannella
GIMEMA
Rome, Italy

Project summary

Evidence-based data on long-term patient- reported Health-Related Quality of Life (HRQOL) in AML survivors, regardless of their treatment in the setting of a randomized controlled trial (RCT) or not, is sparse. The paucity of available evidence shows that shortly after diagnosis and during the course of conventional chemotherapy, physical, psychological, emotional well-being and sexual functions are adversely affected by the disease itself and by the treatment. Significant improvements of HRQOL might be observed over time, paralleling the normalization of bone marrow function and completion of treatment. However, there is still paucity of empirical data in AML patients. With this project, we aim to gather unique knowledge on survivorship issues in AML patients treated both in RCTs and in routine care settings.

Achievements

24 European Centers (Italian and non-Italian Centers) enrolled 225 AML survivors. Study recruitment has been early closed on February 28th, 2022, due to COVID-19 related low accrual rate.

The study recruitment has been stopped in February 2022: potential further participants are not currently being recruited or enrolled.

Statistical analysis and publications

Future plans

All those interested in collaboration might want to contact the PI.

Prof. Fabio Efficace
Head, Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center, Rome, Italy.
E-mail: f.efficace@gimema.it

Frédéric Baron
University of Liège Liège, Belgium
E-mail: f.baron@ulg.ac.be

For patients

This study will investigate Patient-Reported Outcomes, such as Quality of Life (QOL), in long-term AML survivors. It will include a large group of patients who received diagnosis of AML and survived at least 5 years from diagnosis.

All participants will be invited to participate through their hematologist and will be asked to complete a set of questionnaires.

Publications

-Abstract submitted at 2023 American Society of Hematology (ASH) Congress
-Abstract submitted at 2023 Italian society of Hematology Meeting

Long term comorbidity and health problems in acute myeloid leukemia (AML) survivors: an international AML survivorship study. EHA2023 Hybrid Congress Abstract Book, HemaSphere, 2023; 7 (S3); P1686, 3277

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