Acute Myeloid Leukemia Survivors
Project summary
This international, cross-sectional study assessed health-related quality of life (HRQoL), comorbidities, and lifestyle behaviors in long-term AML survivors from six countries. The HRQoL was evaluated using the SF-36 and EORTC QLQ-C30 questionnaires. Comorbidities were assessed with an adapted version of the validated self-Administered Comorbidity questionnaire. Overall, 225 AML survivors with a median time since diagnosis of 8.8 years (IQR 6.4–11.9) and a median age of 58.9 years (IQR 49.0–67.0) were enrolled. Compared with the general population, AML survivors exhibited clinically relevant impairments in the SF-36 physical functioning and role physical scales, alongside clinically relevant lower physical component summary scores. Survivors treated with allogeneic stem cell transplantation reported worse HRQoL profiles compared to those treated with autologous transplant or chemotherapy only. Comorbidities were prevalent in 88.5% of survivors, with impaired vision, back pain, and arthrosis/arthritis being the most common. Analysis of lifestyle behaviors revealed that 66.2% of AML survivors were physically inactive, 80.2% had suboptimal dietary patterns, and 55.3% were overweight/obese. Multivariate analysis identified physical inactivity as the only independent factor associated with worse HRQoL. This study highlights persistent physical limitations and high comorbidity burdens among long-term AML survivors even many years since diagnosis. Interventions to promote adherence to healthy lifestyle behavior, such as physical activity, are to be strongly considered in AML survivorship programs to possibly improve HRQoL outcomes.
Achievements
The study is now completed.
Publications
1. EHA2023 poster presentation: Fabio Efficace, Laura Cannella, Xavier Thomas, Meltem Kurt Yüksel, Silvia Maria Trisolini, Alberto Brini, Ernesta Audisio, Luca Maurillo, Roberto M. Lemoli, Annalisa Imovilli, Irina Panovska-Stavridis, Livio Pagano, Maria Ciccone, Nunzio Filardi, Nicola Stefano Fracchiolla, Daniele Vallisa, Monica Crugnola, Nicola Cascavilla, Matevz Skerget, Marco Vignetti, Frederic Baron, On behalf of the GIMEMA and EORTC Leukemia and Quality of Life Groups. P1686: LONG-TERM COMORBIDITY AND HEALTH PROBLEMS IN ACUTE MYELOID LEUKEMIA (AML) SURVIVORS: AN INTERNATIONAL AML SURVIVORSHIP STUDY. HemaSphere, 7: e90211c0. https://doi.org/10.1097/01.HS9.0000973616.90211.c0
2. SIE 2023 poster presentation: Laura Cannella, Frederic Baron, Xavier Thomas, Meltem Kurt Yuksel, Silvia Maria Trisolini, Capria Saveria, Alberto Brini, Ernesta Audisio, Luca Maurillo, Roberto Massimo Lemoli, Annalisa Imovilli, Irina Panovska Stavridis, Livio Pagano, Maria Ciccone, Nunzio Filardi, Nicola Fracchiolla, Daniele Vallisa, Monica Crugnola, Nicola Cascavilla, Matevz Skerget, Marco Vignetti, Fabio Efficace; DP50 Association of comorbidity and Health-Related Quality of Life in Long-Term Survivors of Acute Myeloid Leukemia. On behalf of the GIMEMA and EORTC Leukemia and Quality of Life Groups. Abstract book 50° CONGRESSO NAZIONALE SIE Società Italiana di Ematologia ROMA, 23-25 Ottobre 2023 Marriott Park Hotel https://drive.google.com/drive/folders/1RzsXN7AR1usmAmX41Cj1khgBYS8PK_1X?usp=drive_link
3. ASH 2023 poster presentation: Fabio Efficace, Laura Cannella, Xavier Thomas, Meltem Kurt Yuksel, Silvia Maria Trisolini, Capria Saveria, Alberto Brini, Ernesta Audisio, Luca Maurillo, Roberto Massimo Lemoli, Annalisa Imovilli, Irina Panovska Stavridis, Martina Quattrone, Maria Ciccone, Nunzio Filardi, Nicola Fracchiolla, Daniele Vallisa, Monica Crugnola, Lorella Maria Antonia Melillo, Matevz Skerget, Marco Vignetti, Frederic Baron; Lifestyle Behaviors and Health-Related Quality of Life in Long-Term Survivors of Acute Myeloid Leukemia: An International Survivorship Study By the Gimema, EORTC Quality of Life and Leukemia Groups. Blood 2023; 142 (Supplement 1): 3801. doi: https://doi.org/10.1182/blood-2023-179248
4. Manuscript SPARTA: Fabio Efficace, Laura Cannella, Xavier Thomas, Meltem Kurt Yuksel, Silvia Maria Trisolini, Saveria Capria, Francesco Sparano, Thomas Baldi, Ernesta Audisio, Luca Maurillo, Roberto Massimo Lemoli, Annalisa Imovilli, Irina Panovska Stavridis, Martina Quattrone, Maria Ciccone, Nunzio Filardi, Nicola Fracchiolla, Daniele Vallisa, Monica Crugnola, Lorella Maria Antonia Melillo, Matevz Skerget, Marco Vignetti, Frederic Baron, on behalf of the EORTC Quality of Life Group. Lifestyle Behaviors and Health-Related Quality of Life in Long-Term Survivors of Acute Myeloid Leukemia: An International Survivorship Study by the GIMEMA, EORTC Quality of Life and Leukemia Groups. Submitted under review