Childhood acute lymphoblastic leukemia

Principal investigator(s)
Caroline Piette
Belgium
, Anne-Sophie Darlington
School of Health Sciences, University of Southampton
Southampton, United Kingdom
Project coordinator(s)
Alison Rowsell
University of Southampton
Southampton, United Kingdom

Project summary

This project focusses on analysing and interpreting Quality of Life (QoL) data collected between 2012 and 2017 during the EORTC CLG 58LAE (Late Adverse Effects) project. The original project investigated long-term outcomes in childhood acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) survivors (≥18 years) who were enrolled as children (<18 years) in the EORTC CLG treatment protocols 58741 (1971-1978), 58831/2 (1983-1989), and 58881 (1989–1998).

During this project we report on QoL data from three questionnaires completed by survivors: The SF12, The Impact of Cancer for Childhood Cancer Survivors (IOC-CS) and the Quality of Life Systemic Inventory (QLSI).

We are working on three manuscripts linked to this project: 1) Quality of life of long-term childhood acute lymphoblastic leukemia survivors enrolled between 1971 and 1998 in EORTC CLG studies compared to healthy controls: results of the 58LAE study; 2) Sociodemographic and medical determinants of long-term quality of life in acute lymphoblastic leukemia survivors an EORTC investigation; 3) The use of Health Status and Quality of Life measures in long-term childhood acute lymphoblastic leukemia survivors enrolled in EORTC CLG studies: a methodological perspective.

Achievements

1 Manuscript has been published:

Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies – PMC (nih.gov)

1 Manuscript has been submitted to a journal and was rejected, and will be resubmitted to Psycho-Oncology pending some final changes

1 Manuscript is still in preparation

Future plans

Submission and publication of the 2 remaining manuscripts

For patients

This project looks at Quality of Life (QoL) of a group of survivors of childhood cancer (acute lymphoblastic leukemia). The data was collected between 2012 and 2017. Here we look at the long-term impacts of childhood cancer on QoL compared to healthy people. We also explore whether there are medical or social influences on QoL. Finally, we look at the questionnaires used to measure QoL and how useful these are for capturing the experiences of survivors.