Principal investigator(s)
Martin Klein
Amsterdam, Netherlands
, Jaap Reijneveld
VU University Medical Center / Amsterdam Medical Center
Amsterdam, Netherlands
Project coordinator(s)
Ivan Caramanna
Amsterdam, Netherlands

Project summary

In glioma patients the correlation of self-rated cognitive abilities with HRQOL was never compared with that of objective abilities, nor has the concomitant influence of tumor- and treatment-related and demographic variables ever been taken into consideration. Furthermore, studies on the impact of cognitive functioning on differences between HRQOL-ratings by patients and proxies show contradictory results. On these grounds, given the significant risk of cognitive impairment in brain tumor patients, this study aims at clarifying the impact of self-awareness of cognitive deficits and objective cognitive deficits on self-reported HRQOL and to evaluate if such an impact is a by-product of tumor- and treatment-related variables. Perceived and objective deficits are expected to affect HRQOL differently.


First manuscript under review, second manuscript ready to be circulated and third one in progress.

Future plans

Second manuscript will be submitted to journal as soon as reviewed, third one will follow

For patients

It is common for people having a brain tumour to struggle to concentrate or pay attention as well as not to behave anymore as before the tumour. The health-related Quality of Life score measures how physically and mentally someone is feeling during treatment. We want to know if  what is happening to them and being aware of it could influence the way patients report their health-related quality of life.