Principal investigator(s)
Mogens Grønvold
University of Copenhagen
Copenhagen, Denmark
, Morten Aa. Petersen
Denmark
Project coordinator(s)
Morten Aa. Petersen
Denmark

Project summary

To optimize measurement precision and flexibility a computerized adaptive test version of the EORTC QLQ-C30 has been developed. In CAT assessment, the selection of items is tailored to the individual based on responses to prior items. Item banks, from which the CAT selects items, have been developed for all symptom and functional domains of the QLQ-C30. These each comprise between 7-34 items and the new instrument comprises a total of 262 items. Evaluations indicate higher measurement precision and thereby increased statistical power of the CAT compared to the QLQ-C30. Thus, using the CAT, sample sizes may be reduced by approximately 20-35% on average without loss of power.

More info

Achievements

  • Developed CAT item banks of 7-34 items for the symptom and functional domains of the EORTC QLQ-C30. The new instrument comprises a total of 262 items.
  • Developed software for conducting online CAT assessment and for selecting items for short forms
  • Collected general population data from 13 European countries (plus from USA and Canada) to norm the EORTC CAT scoring and to be used as reference data.
  • Validated the CAT system in an international sample of cancer patients

Future plans

  • Finalise validation of the CAT
  • Update all CAT related software
  • Generate a selection of ‘ready to use’ standard CAT-settings and short forms with different properties
  • Examine the relevance of splitting up and/or expanding the current item banks

For patients

Knowledge about an individual’s health-related quality of life is typically obtained using questionnaires. In standard questionnaires everyone answers the same questions, but this means some questions may not be relevant/informative for some individuals. Computerized adaptive testing is a technic that allows for selecting questions, using a specialized computer program, particularly relevant for the individual. The EORTC has developed an adaptive version of the EORTC QLQ-C30 questionnaire. This adaptive version allows for more precise and personalized measurement of health-related quality of life.

Publications

  • Petersen MA, Groenvold M, Aaronson NK, Chie WC, Conroy T, Costantini A et al (2010). Development of computerised adaptive testing (CAT) for the EORTC QLQ-C30 dimensions – General approach and initial results for physical functioning. European Journal of Cancer, 46, 1352-1358.
  • Petersen MA, Groenvold M, Aaronson NK, Chie WC, Conroy T, Costantini A et al (2011). Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30 physical functioning dimension. Quality of Life Research, 20(4), 479-490.
  • Giesinger JM, Petersen MA, Groenvold M, Aaronson NK, Arraras JI, Conroy T et al (2011). Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients. Health Qual Life Outcomes, 9(19)
  • Petersen MA, Aaronson NK, Arraras JI, Chie WC, Conroy T, Costantini A et al (2012). The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency. Journal of Clinical Epidemiology, 66(3), 330-339.
  • Petersen MA, Giesinger JM, Holzner B, Arraras JI, Conroy T, Gamper EM et al (2013). Psychometric evaluation of the EORTC computerized adaptive test (CAT) fatigue item pool. Quality of Life Research, 22(9), 2443-2454.
  • Petersen MA, Groenvold M. (2013). Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30. MAPI PRO Newsletter, Spring 2013
  • Gamper EM, Groenvold M, Petersen MA, Young T, Costantini A, Aaronson NK et al (2014). The EORTC Emotional Functioning computer adaptive test (CAT): phase I-III of a cross-cultural item bank development. Psycho-Oncology, 23, 397-403.
  • Thamsborg LH, Petersen MA, Aaronson NK, Chie WC, Costantini A, Holzner B et al (2014). Development of a lack of appetite item bank for computer-adaptive testing (CAT). Support Care Cancer, 23(6), 1541-1548.
  • Petersen MA, Aaronson NK, Chie WC, Conroy T, Costantini A, Hammerlid E et al (2015). Development of an item bank for computerized adaptive test (CAT) measurement of pain. Quality of Life Research, Epub ahead of print.
  • Petersen MA, Gamper EM, Costantini A, Giesinger JM, Holzner B, Johnson C et al (2015). An emotional functioning item bank of 24 items for computer adaptive testing (CAT) was established. Journal of Clinical Epidemiology, 70, 90-100.
  • Gamper EM, Petersen MA, Aaronson NK, Costantini A, Giesinger JM, Holzner B et al (2016). Development of an Item Bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT). Health Qual Life Outcomes, 14(72)
  • Dirven L, Taphoorn MJ, Groenvold M, Habets EJJ, Aaronson NK, Conroy T et al (2016). Development of an item bank for computerized adaptive testing of self-reported cognitive difficulty in cancer patients. Neuro-Oncology Practice
  • Dirven L, Groenvold M, Taphoorn MJ, Conroy T, Tomaszewski KA, Young T, Petersen MA. (2017). Psychometric evaluation of an item bank for computerized adaptive testing of the EORTC QLQ-C30 cognitive functioning dimension in cancer patients. Quality of Life Research