Comparing EORTC CAT
Project summary
The project aims at comparing the computer-adaptive EORTC quality of life measures against other important patient-reported outcome (PRO) measures in the field that assess the same or similar constructs. The comparator instruments were selected for similarity of assessed domains, for being widely used in cancer research and for expected relevance in future cancer research. The projects includes a conceptual comparison of the PRO measures, the exploration of the possibility to link the EORTC measures to the comparator measures and the investigation of the relative validity of the EORTC measures and the comparator measures in known-group comparisons
The project aims at comparing various questionnaires that are used for the assessment of quality of life, symptoms and problems in cancer patients. The comparisons will focus on questionnaire content and measurement precision.
Achievements
Recruitment for three out of six parallel study samples has been finished and the first three original articles from the project have been published.
Qualitative analyses for aim A and recruitment for aim B and C are ongoing. Quantitative analyses for aim B and C have started for the domains included in the samples for which recruitment has been finished (i.e. physical, role, social and emotional functioning, and pain). For support of the statistical analyses, a collaboration has been started with the Institute of Mathematics at the University of Innsbruck (Prof. Hell).
Current status:
Qualitative analyses for aim A and recruitment for aim B and C are ongoing. Quantitative analyses for aim B and C have started for the domains included in the samples for which recruitment has been finished (i.e. physical, role, social and emotional functioning, and pain). For support of the statistical analyses, a collaboration has been started with the Institute of Mathematics at the University of Innsbruck (Prof. Hell).
Future plans
Recruitment for the three remaining parallel study samples and publication of study results.
For patients
The project aims at comparing various questionnaires that are used for the assessment of quality of life, symptoms and problems in cancer patients. The comparisons will focus on questionnaire content and measurement precision.
Publications
Published:
- Content comparison of the EORTC CAT Core, SF-36, FACT-G, and PROMIS role and social functioning measures based on the International Classification of Functioning, Disability and Health. Pilz MJ, Rothmund M, Lidington E, Piccinin C, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM; EORTC Quality of Life Group. Psychooncology. 2023 Jul 25. doi: 10.1002/pon.6188.
- Patient-reported outcome measures for emotional functioning in cancer patients: Content comparison of the EORTC CAT Core, FACT-G, HADS, SF-36, PRO-CTCAE, and PROMIS instruments.
- Rothmund M, Pilz MJ, Egeter N, Lidington E, Piccinin C, Arraras JI, Grønvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM; EORTC Quality of Life Group. Psychooncology. 2023 Jan 27. doi: 10.1002/pon.6109.
- Patient-reported outcome measures for physical function in cancer patients: content comparison of the EORTC CAT Core, EORTC QLQ-C30, SF-36, FACT-G, and PROMIS measures using the International Classification of Functioning, Disability and Health.
- Schurr T, Loth F, Lidington E, Piccinin C, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM; European Organisation for Research, Treatment of Cancer Quality of Life Group (EORTC QLG). BMC Med Res Methodol. 2023 Jan 21;23(1):21. doi: 10.1186/s12874-022-01826-z.
Currently submitted:
- Equipercentile equating of scores from common patient-reported outcome measures of physical function in patients with cancer
Rothmund M, Pilz JM, Schlosser L, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Rose M, Cella D, Giesinger JM on behalf of the EORTC Quality of Life Group (under review at J Clin Epidem)
Currently being drafted:
- Comparing the contents of patient-reported outcome measures for fatigue: EORTC CAT Core, EORTC-QLQ-FA12, FACIT, PRO-CTCAE, PROMIS, Brief Fatigue Inventory, Multidimensional Fatigue Inventory, and Piper Fatigue Scale
Rothmund M, Pilz MJ, Egeter N, Lidington E, Piccinin C, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM on behalf of the EORTC Quality of Life Group - Equipercentile equating of scores from common patient-reported outcome measures of role and social function in patients with cancer
- Rothmund M, Pilz JM, Schlosser L, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Rose M, Cella D, Giesinger JM on behalf of the EORTC Quality of Life Group