Comparing EORTC CAT
Project summary
The project aims at comparing the computer-adaptive EORTC quality of life measures against other important patient-reported outcome (PRO) measures in the field that assess the same or similar constructs. The comparator instruments were selected for similarity of assessed domains, for being widely used in cancer research and for expected relevance in future cancer research. The project includes a conceptual comparison of the PRO measures (aim A), the exploration of the possibility to link the EORTC measures to the comparator measures (aim B) and the investigation of the relative validity of the EORTC measures and the comparator measures in known-group comparisons (aim C).
Achievements
Recruitment for all study samples has been finished and the first five original articles from the project have been published.
Qualitative analyses for aim A and recruitment for aim B and C are ongoing. Quantitative analyses for aims B and C have started for the domains included in the samples for which recruitment has been finished (i.e. physical, role, social and emotional functioning, and pain).
Future plans
Final data analysis is ongoing.
For patients
The project aims at comparing various questionnaires that are used for the assessment of quality of life, symptoms and problems in cancer patients. The comparisons will focus on questionnaire content and measurement precision.
Publications
- Rothmund M, Pilz MJ, Egeter N, Lidington E, Piccinin C, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Ramage J, Schmidt H, Young T, Giesinger JM; EORTC Quality of Life Group. Comparing the contents of patient-reported outcome measures for fatigue: EORTC CAT Core, EORTC QLQ-C30, EORTC QLQ-FA12, FACIT, PRO-CTCAE, PROMIS, Brief Fatigue Inventory, Multidimensional Fatigue Inventory, and Piper Fatigue Scale. Health Qual Life Outcomes. 2024 Dec 2;22(1):104. doi: 10.1186/s12955-024-02316-0. PMID: 39623483; PMCID: PMC11613840.
- Pilz MJ, Rothmund M, Lidington E, Piccinin C, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM; EORTC Quality of Life Group. Content comparison of the EORTC CAT Core, SF-36, FACT-G, and PROMIS role and social functioning measures based on the International Classification of Functioning, Disability and Health. Psychooncology. 2023 Jul 25. doi: 10.1002/pon.6188.
- Rothmund M, Pilz MJ, Egeter N, Lidington E, Piccinin C, Arraras JI, Grønvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM; EORTC Quality of Life Group. Patient-reported outcome measures for emotional functioning in cancer patients: Content comparison of the EORTC CAT Core, FACT-G, HADS, SF-36, PRO-CTCAE, and PROMIS instruments. Psychooncology. 2023 Apr;32(4):628-639. doi: 10.1002/pon.6109. Epub 2023 Feb 19. PMID: 36707461.
- Schurr T, Loth F, Lidington E, Piccinin C, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Giesinger JM; European Organisation for Research, Treatment of Cancer Quality of Life Group (EORTC QLG). Patient-reported outcome measures for physical function in cancer patients: content comparison of the EORTC CAT Core, EORTC QLQ-C30, SF-36, FACT-G, and PROMIS measures using the International Classification of Functioning, Disability and Health. BMC Med Res Methodol. 2023 Jan 21;23(1):21. doi: 10.1186/s12874-022-01826-z. PMID: 36681808; PMCID: PMC9862545.
- Rothmund M, Pilz MJ, Schlosser L, Arraras JI, Groenvold M, Holzner B, van Leeuwen M, Petersen MA, Schmidt H, Young T, Rose M, Cella D, Giesinger JM; EORTC Quality of Life Group. Equipercentile equating of scores from common patient-reported outcome measures of physical function in patients with cancer. J Clin Epidemiol. 2024 Jan;165:111203. doi: 10.1016/j.jclinepi.2023.10.019. Epub 2023 Oct 31. PMID: 37918641.