Lung Cancer (update of QLQ-LC13)

Gender Neutral
Type Module
Testing Phase IV - completed
Principal investigator(s)
Michael Koller
Regensburg, Germany

Project summary

The update of the EORTC questionnaire for assessing quality of life in lung cancer follows a rigorous methodology including patient involvement on various levels. The updated questionnaire after Phases 1 to 3 comprises, in addition to the original items, new items related to the side-effects of targeted therapies and surgery. The updated module currently undergoes full validation and psychometric testing in a cross-cultural, multicenter Phase 4 study, involving 19 centers from 12 different countries. The updated module should become the new standard for quality of life assessment in lung cancer clinical trials.

Achievements

Phase 3 paper published in major journal. Phase 4 recruitment completed. Phase 4 analyses ongoing.

Future plans

Phase 4 paper/report by Q2.

For patients

Quality of life is a major concern for lung cancer patients. Two decades ago the EORTC has developed a lung cancer module to assess patients’ quality of life. The goal of the current project is to update this module in order to catch up with new developments in the diagnosis and treatment for patients with lung cancer.

Publications

Koller M, Hjermstad MJ,Tomaszewski KA, Tomaszewska IM, Hornslien K, Harle A, Arraras JI, Morag O, Pompili C, Ioannidis G, Georgiou M, Navarra C, Chie WC, Johnson CD, Himpel A, Schulz C, Bohrer T, Janssens A, Kuliś D, Bottomley A on behalf of the EORTC Quality of Life Group, EORTC Lung Cancer Group, and European Society of Thoracic Surgeons. An international study to revise the EORTC questionnaire for assessing quality of life in lung cancer patients Ann Oncol. 2017 Nov 1;28(11):2874-2881. doi: 10.1093/annonc/mdx453.

Koller M, Hjermstad MJ, Tomaszewski KA, Harle A, Arraras JI, Morag O, Pompili C, Ioannidis G, Navarra C, Chie WC, Johnson C, Himpel A, Schulz C, Hofmann HS, Müller K, Kulis D, Bottomley A. Update of the EORTC module for assessing quality of life in patients with lung cancer – introducing the EORTC QLQ-LC29. 16. Deutscher Kongress für Versorgungsforschung (DKVF). Berlin, 04.-06.10.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DOI: 10.3205/17dkvf022

Koch Myriam, Zeman Florian, Hjermstad Jensen Marianne, Tomaszewski Krzysztof, Tomaszewska Iwona, Hornslien Kjersti, Harle Amelie, Arraras Juan, Morag Ofir, Pompili Cecilia, Ioannidis Georgios, Georgu Morfo, Navarra Chiara, Chie Weichu, Johnson Colin, Himpel Ayje, Bohrer Thomas, Janssens Annelies, Kulis Dagmara, Bottomley Andrew, Schulz Christian, Koller Michael (Poster and Abstract), ERS, Paris Sept. 2018