Threshold for the EORTC QLQ-C30 and CAT
Project summary
To improve interpretation of patient-reported outcome (PRO) data collected with the EORTC QOL measures the project develops thresholds for clinical importance. These thresholds will facilitate interpretation of QOL scores collected in daily clinical practice and of trial results.
Achievements
All planned papers are published.
Future plans
The study is completed.
For patients
The EORTC quality of life questionnaires are used to assess the perspective of cancer patients on their disease and its treatment. Such questionnaires allow to calculate scores that reflect the degree of a symptom or problem. Relying on interviews with cancer patients and health professionals, this project develops thresholds that help to determine what degree of a symptom or problem should be considered clinically important.
Publications
- Pilz MJ, Aaronson NK, Arraras JI, Caocci G, Efficace F, Groenvold M, Holzner B, van Leeuwen M, Loth FLC, Petersen MA, Ramage J, Tomaszewski KA, Young T, Giesinger JM. Evaluating the Thresholds for Clinical Importance of the EORTC QLQ-C15-PAL in Patients Receiving Palliative Treatment. J Palliat Med. 2021 Mar;24(3):397-404.
- Giesinger JM, Loth FLC, Aaronson NK, Arraras JI, Caocci G, Efficace F, Groenvold M, van Leeuwen M, Petersen MA, Ramage J, Tomaszewski KA, Young T, Holzner B; EORTC Quality of Life Group. Thresholds for clinical importance were established to improve interpretation of the EORTC QLQ-C30 in clinical practice and research. J Clin Epidemiol. 2020 Feb;118:1-8.
- Giesinger JM, Loth FLC, Aaronson NK, Arraras JI, Caocci G, Efficace F, Groenvold M, van Leeuwen M, Petersen MA, Ramage J, Tomaszewski KA, Young T, Holzner B; EORTC Quality of Life Group. Thresholds for clinical importance were defined for the European Organisation for Research and Treatment of Cancer Computer Adaptive Testing Core-an adaptive measure of core quality of life domains in oncology clinical practice and research. J Clin Epidemiol. 2020 Jan;117:117-125.
- Giesinger JM, Aaronson NK, Arraras JI, Efficace F, Groenvold M, Kieffer JM, Loth FL, Petersen MA, Ramage J, Tomaszewski KA, Young T, Holzner B; EORTC Quality of Life Group. A cross-cultural convergent parallel mixed methods study of what makes a cancer-related symptom or functional health problem clinically important. Psychooncology. 2018 Feb;27(2):548-555.